2 papers
stat.AP2026
Estimands and the Choice of Non-Inferiority Margin under ICH E9(R1)
Tobias Mütze, Helle Lynggaard, Sunita Rehal +3
Since the release of the ICH E9(R1) addendum on estimands, its application in non-inferiority trials has received far less attention than in superiority settings. A key conclusion…
stat.ME2024
The Estimand Framework and Causal Inference: Complementary not Competing Paradigms
Thomas Drury, Jonathan W. Bartlett, David Wright +1
The creation of the ICH E9 (R1) estimands framework has led to more precise specification of the treatment effects of interest in the design and statistical analysis of clinical tr…