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stat.ME2026
How to optimize dynamic borrowing in basket trials - A utility-based framework and results of a comparison study
Lukas D Sauer, Alexander Ritz, Meinhard Kieser
Basket trials are clinical trials in which one treatment is investigated in multiple subpopulations within a single trial. The subpopulations are called strata in the following. St…
stat.ME2024
Utility-based optimization of Fujikawa's basket trial design -- Pre-specified protocol of a comparison study
Lukas D Sauer, Alexander Ritz, Meinhard Kieser
Basket trial designs are a type of master protocol in which the same therapy is tested in several strata of the patient cohort. Many basket trial designs implement borrowing mechan…
stat.ME2024
A basket trial design based on power priors
Lukas Baumann, Lukas Sauer, Meinhard Kieser
In basket trials a treatment is investigated in several subgroups. They are primarily used in oncology in early clinical phases as single-arm trials with a binary endpoint. For the…