245 citations · 402 across the 22 of their papers we have counts for
4 papers · 1 filter
Ab initio computational modeling of tumor spheroids
Roberto Chignola, Alessio Del Fabbro, Marcello Farina +1
This paper is a review of the VBL project, where we develop and test a numerical simulator of tumor spheroids.
Balance between cell survival and death: a minimal quantitative model of tumor necrosis factor alpha cytotoxicity
Roberto Chignola, Marcello Farina, Alessio Del Fabbro +1
Tumor Necrosis Factor alpha (TNF) initiates a complex series of biochemical events in the cell upon binding to its type R1 receptor (TNF-R1). Recent experimental work has unravelle…
Numerical integration methods for large-scale biophysical simulations
Roberto Chignola, Alessio Del Fabbro, Edoardo Milotti
Simulations of biophysical systems inevitably include steps that correspond to time integrations of ordinary differential equations. These equations are often related to enzyme act…
Precision and Stability Issues in VBL, the Virtual Biophysics Lab simulation program
Edoardo Milotti, Alessio Del Fabbro, Roberto Chignola
The network of biochemical reactions inside living organisms is characterized by an overwhelming complexity which stems from the sheer number of reactions and from the complicated…