245 citations · 364 across the 10 of their papers we have counts for
6 papers · 1 filter
Numerical integration methods for large-scale biophysical simulations
Roberto Chignola, Alessio Del Fabbro, Edoardo Milotti
Simulations of biophysical systems inevitably include steps that correspond to time integrations of ordinary differential equations. These equations are often related to enzyme act…
Precision and Stability Issues in VBL, the Virtual Biophysics Lab simulation program
Edoardo Milotti, Alessio Del Fabbro, Roberto Chignola
The network of biochemical reactions inside living organisms is characterized by an overwhelming complexity which stems from the sheer number of reactions and from the complicated…
Ab initio phenomenological simulation of the growth of large tumor cell populations
Roberto Chignola, Alessio Del Fabbro, Chiara Dalla Pellegrina +1
In a previous paper we have introduced a phenomenological model of cell metabolism and of the cell cycle to simulate the behavior of large tumor cell populations (Chignola R and Mi…
Dynamical hysteresis in multisite protein modification
Edoardo Milotti, Alessio Del Fabbro, Chiara Dalla Pellegrina +1
Multisite protein modification is a ubiquitous mechanism utilized by cells to control protein functions. We have recently proposed a dynamical description of multisite protein modi…
Fine-grained Delaunay triangulation in a simulation of tumor spheroid growth
Alessio Del Fabbro, Roberto Chignola, Edoardo Milotti
The simulation of many-particle systems often requires the detailed knowledge of proximity relations to reduce computational complexity and to provide a basis for specific calculat…
A phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations
Roberto Chignola, Edoardo Milotti
A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring a…