A Simulation-Driven Digital Workflow Integrating Bayesian Optimization for Early-Stage Process Design: A Methyl Acetate Production Case Study

Trung Ngoc Trinh, Trung Thanh Nguyen, Nikolaos Tsakoumis +1

Methyl acetate production via direct carbonylation of dimethyl ether and carbon monoxide involves strong nonlinear interactions among reactor operation, recycle structure, and ener…