3 papers
nlin.AO2026
Molecular-scale, nonlinear actomyosin binding dynamics drive population-scale adaptation and evolutionary convergence
Jake McGrath, Colin Johnson, José Alvarado
Biological actuators -- from myosin motors to muscles -- follow Hill's model where a dimensionless parameter captures the nonlinear coupling between contraction rate and force…
cond-mat.soft2025
Control across scales: signals, information, and adaptive biological mechanical function
James Clarke, Jake McGrath, Colin Johnson +1
Biological systems perform an astonishing array of dynamical processes -- including development and repair, regulation, behavior and motor control, sensing and signaling, and adapt…
physics.bio-ph2024
Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems
Jake McGrath, Brian Kent, Colin Johnson +1
Myosin motors are fundamental biological actuators, powering diverse mechanical tasks in eukaryotic cells via ATP hydrolysis. Recent work revealed that myosin's velocity-dependent…