4 papers
CTG-DB: An Ontology-Based Transformation of ClinicalTrials.gov to Enable Cross-Trial Drug Safety Analyses
Jeffery L. Painter, François Haguinet, Andrew Bate
ClinicalTrials .gov (CT .gov) is the largest publicly accessible registry of clinical studies, yet its registry-oriented architecture and heterogeneous adverse event (AE) terminolo…
Semantic Similarity-Informed Bayesian Borrowing for Quantitative Signal Detection of Adverse Events
François Haguinet, Jeffery L Painter, Gregory E Powell +2
We present a Bayesian dynamic borrowing (BDB) approach to enhance the quantitative identification of adverse events (AEs) in spontaneous reporting systems (SRSs). The method embeds…
Ontology-based Semantic Similarity Measures for Clustering Medical Concepts in Drug Safety
Jeffery L Painter, François Haguinet, Gregory E Powell +1
Semantic similarity measures (SSMs) are widely used in biomedical research but remain underutilized in pharmacovigilance. This study evaluates six ontology-based SSMs for clusterin…
PVLens: Enhancing Pharmacovigilance Through Automated Label Extraction
Jeffery L Painter, Gregory E Powell, Andrew Bate
Reliable drug safety reference databases are essential for pharmacovigilance, yet existing resources like SIDER are outdated and static. We introduce PVLens, an automated system th…