5 papers
Beyond the Tumor: Recurrence-Prone Radiomics for Prognostication in Negative PSMA PET/CT scans of Prostate Cancer
Fereshteh Yousefirizi, Sara Harsini, Mobin Mohebi +14
In patients with biochemical recurrence of prostate cancer and negative PSMA PET/CT, radiomics features extracted from recurrence-prone organs can predict clinical progression and…
Virtual Theranostic Trials: New Approach Methodologies (NAMs) and Precision Radiopharmaceutical Therapies
Carlos F. Uribe, Hamid Abdollahi, Tahir Yusufaly +7
Radiopharmaceutical therapies are expanding rapidly, but clinical evidence generation is limited by operational constraints and biological heterogeneity in radiopharmaceutical deli…
Nuclear Medicine AI in Action: The Bethesda Report (AI Summit 2024)
Arman Rahmim, Tyler J. Bradshaw, Guido Davidzon +10
The 2nd SNMMI Artificial Intelligence (AI) Summit, organized by the SNMMI AI Task Force, took place in Bethesda, MD, on February 29 - March 1, 2024. Bringing together various commu…
Verification, Validation, and Uncertainty Quantification (VVUQ) of Physiologically Based Pharmacokinetic Models for Theranostic Digital Twins: Towards Reliable Model-Informed Treatment Planning for Radiopharmaceutical Therapies
Nouran R. R. Zaid, Deni Hardiansyah, Tahir Yusufaly +1
Physiologically based pharmacokinetic (PBPK) models provide a mechanistic framework for simulating radiopharmaceutical kinetics and estimating patient-specific absorbed doses (ADs)…
Quantitative and Computational Radiobiology for Precision Radiopharmaceutical Therapies
Tahir Yusufaly, Hamid Abdollahi, Babak Saboury +1
This article reviews the evolving field of radiobiology, emphasizing the need for advanced multiscale, mechanistic models to optimize radiopharmaceutical therapies (RPT). While the…