3 papers
stat.ME2026
Toward Efficient Estimation of Regional Treatment Effects in Multi-Regional Clinical Trials
Zhiwei Zhang, Yongwu Shao, Wei Zhang +1
A multi-regional clinical trial (MRCT) is a single clinical trial conducted in multiple regions simultaneously under a common protocol, which may be used to support parallel submis…
stat.ME2025
An adaptive design for optimizing treatment assignment in randomized clinical trials
Wei Zhang, Zhiwei Zhang, Aiyi Liu
The treatment assignment mechanism in a randomized clinical trial can be optimized for statistical efficiency within a specified class of randomization mechanisms. Optimal designs…
stat.ME2025
Optimal Treatment Allocations Accounting for Population Differences
Wei Zhang, Zhiwei Zhang, Aiyi Liu
The treatment allocation mechanism in a randomized clinical trial can be optimized by maximizing the nonparametric efficiency bound for a specific measure of treatment effect. Opti…