4 papers
SynCell: Contextualized Drug Synergy Prediction
Keqin Peng, Guangxin Su, Qinshan Shi +4
Drug synergy is profoundly influenced by cellular context, as variations in protein interaction landscapes and pathway activities across cell types reshape how drugs act in combina…
HyperADRs: A Hierarchical Hypergraph Framework for Drug-Gene-ADR Prediction
Ze Cai, Haotian Tang, Shuai Gao +3
Adverse drug reactions (ADRs) are a major barrier to safe and effective pharmacotherapy and increasingly reflect higher order interactions between drugs, genetic background, and cl…
HODDI: A Dataset of High-Order Drug-Drug Interactions for Computational Pharmacovigilance
Zhaoying Wang, Yingdan Shi, Xiang Liu +3
Drug-side effect research is vital for understanding adverse reactions arising in complex multi-drug therapies. However, the scarcity of higher-order datasets that capture the comb…
Heterogeneous Entity Representation for Medicinal Synergy Prediction
Jiawei Wu, Jun Wen, Mingyuan Yan +4
Medicinal synergy prediction is a powerful tool in drug discovery and development that harnesses the principles of combination therapy to enhance therapeutic outcomes by improving…