5 papers
A Nonparametric Bayesian Local-Global Model for Enhanced Adverse Event Signal Detection in Spontaneous Reporting System Data
Xin-Wei Huang, Saptarshi Chakraborty
Spontaneous reporting system databases are key resources for post-marketing surveillance, providing real-world evidence (RWE) on the adverse events (AEs) of regulated drugs or othe…
Towards Universal Spatial Transcriptomics Super-Resolution: A Generalist Physically Consistent Flow Matching Framework
Xinlei Huang, Weihao Dai, Zijun Qin +5
Spatial transcriptomics provides an unprecedented perspective for deciphering tissue spatial heterogeneity. However, high-resolution spatial transcriptomic technology remains const…
Subgroup Identification and Individualized Treatment Policies: A Tutorial on the Hybrid Two-Stage Workflow
Nan Miles Xi, Xin Huang, Lin Wang
Patients in clinical studies often exhibit heterogeneous treatment effect (HTE). Classical subgroup analyses provide inferential tools to test for effect modification, while modern…
Bridging the genotype-phenotype gap with generative artificial intelligence
Yangfan Liu, Xiong Xiong, Yong Liao +18
The genotype-phenotype gap is a persistent barrier to complex trait genetic dissection, worsened by the explosive growth of genomic data (1.5 billion variants identified in the UK…
Synergy-Informed Design of Platform Trials for Combination Therapies
Nan Miles Xi, Man Mandy Jin, Lin Wang +1
Combination drug therapies hold significant promise for enhancing treatment efficacy, particularly in fields such as oncology, immunotherapy, and infectious diseases. However, desi…