4 papers
Subspace Tensor Orthogonal Rotation Model (STORM) for Batch Alignment, Cell Type Deconvolution, and Gene Imputation in Spatial Transcriptomic Data
Sean Cottrell, Guo-Wei Wei, Longxiu Huang
Spatial transcriptomics data analysis integrates cellular transcriptional activity with spatial coordinates to identify spatial domains, infer cell-type dynamics, and characterize…
Multiscale Grassmann Manifolds for Single-Cell Data Analysis
Xiang Xiang Wang, Sean Cottrell, Guo-Wei Wei
Single-cell data analysis seeks to characterize cellular heterogeneity based on high-dimensional gene expression profiles. Conventional approaches represent each cell as a vector i…
Computational Drug Repurposing for Alzheimer's Disease via Sheaf Theoretic Population-Scale Analysis of snRNA-seq Data
Sean Cottrell, Seungmin Yoon, Xiaoqi Wei +2
Single-cell and single-nucleus RNA sequencing (scRNA-seq /snRNA-seq) are widely used to reveal heterogeneity in cells, showing a growing potential for precision and personalized me…
Meta-analysis and Topological Perturbation in Interactomic Network for Anti-opioid Addiction Drug Repurposing
Chunhuan Zhang, Sean Cottrell, Benjamin Jones +5
The ongoing opioid crisis highlights the urgent need for novel therapeutic strategies that can be rapidly deployed. This study presents a novel approach to identify potential repur…