3 papers
cs.LG2026
ScreenShot: A Foundation Model for Few-Shot Combination Drug Screening
Antoine de Mathelin, Christopher Tosh, Wesley Tansey
Treating patients with combinations of drugs reduces the risk of resistance to any individual drug. Finding effective combinations is difficult because the large search space makes…
cs.LG2025
Addressing the Cold-Start Problem for Personalized Combination Drug Screening
Antoine de Mathelin, Christopher Tosh, Wesley Tansey
Personalizing combination therapies in oncology requires navigating an immense space of possible drug and dose combinations, a task that remains largely infeasible through exhausti…
stat.ME2025
Treatment response as a latent variable
Christopher Tosh, Boyuan Zhang, Wesley Tansey
Scientists often need to analyze the samples in a study that responded to treatment in order to refine their hypotheses and find potential causal drivers of response. Natural varia…