4 papers
Optimality of mutation and selection in germinal centers
Jingshan Zhang, Eugene I. Shakhnovich
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models e…
Slowly replicating lytic viruses: pseudolysogenic persistence and within-host competition
Jingshan Zhang, Eugene I. Shakhnovich
We study the population dynamics of lytic viruses which replicate slowly in dividing host cells within an organism or cell culture, and find a range of viral replication rates that…
Sensitivity dependent model of protein-protein interaction networks
Jingshan Zhang, Eugene I. Shakhnovich
The scale free structure p(k)~k^{-gamma} of protein-protein interaction networks can be reproduced by a static physical model in simulation. We inspect the model theoretically, and…
Does Logarithm Transformation of Microarray Data Affect Ranking Order of Differentially Expressed Genes?
Wentian Li, Young Ju Suh, Jingshan Zhang
A common practice in microarray analysis is to transform the microarray raw data (light intensity) by a logarithmic transformation, and the justification for this transformation is…