5 papers
Preservation Constraints on aDNA Information Generation and the HSF Posterior Sourcing Framework: A First-Principles Critique of Conventional Methods
Wan-Qian Zhao, Shu-Jie Zhang, Zhan-Yong Guo +1
Fossil DNA preservation varies with depositional environments and diagenesis, producing fragments of heterogeneous origins and degradation states. We use first-principles biomolecu…
Sedimentary models of fossil biomolecules, principles and methodological improvements
Wan-Qian Zhao, Li-Juan Zhao
Deamination has historically been important for authenticating ancient biomolecules. However, expanding paleogenomic datasets indicate that damage patterns are more influenced by b…
DNA Fragments in Crude Oil Reveals Earth's Hidden History
Wan-Qian Zhao, Zhan-Yong Guo, Yu-Qi Guo +16
This groundbreaking research extracted DNA from petroleum using nanoparticle affinity bead technology, yielding 3,159,020 petroleum DNA (pDNA) sequences, primarily environmental DN…
Ancient DNA from 120-Million-Year-Old Lycoptera Fossils Reveals Evolutionary Insights
Wan-Qian Zhao, Zhan-Yong Guo, Zeng-Yuan Tian +20
High quality ancient DNA (aDNA) is essential for molecular paleontology. Due to DNA degradation and contamination by environmental DNA (eDNA), current research is limited to fossil…
Emerging Challenges in Molecular Paleontology: Misapplication of Environmental DNA Fragments and Misconception of Deamination as a Key Criterion for In Situ DNA Identification
Wan-Qian Zhao, Shu-Jie Zhang, Zhan-Yong Guo +9
This article critically examines the methodologies applied in ancient DNA (aDNA) research, particularly those developed by Dr. Pääbo's team, which have significantly influenced t…