3 papers
stat.ME2026
adabay: an R package for rapid evaluation and calibration of Bayesian group sequential designs across common endpoint types
Zhangyi He, Feng Yu
Bayesian group sequential designs (GSDs) combine the efficiency of frequentist GSDs with clinically interpretable probability statements and principled external evidence incorporat…
stat.ME2026
Rapid evaluation and calibration of Bayesian group sequential designs via conjugate-mixture semi-simulation
Zhangyi He, Feng Yu, Suzie Cro +1
Bayesian group sequential designs (GSDs) extend frequentist GSDs with interpretable decision-making and external evidence borrowing, but their use is limited by the computational b…
stat.ME2025
A Bayesian model-free dose-finding approach in Phase II clinical trials with the flexibility of historical borrowing
Linxi Han, Qiqi Deng, Feng Yu +1
Accurate dose selection in Phase II trials is critical to the success of subsequent Phase III trials, but suboptimal choices remain a leading cause of trial failure and regulatory…