most citedIsoform reconstruction using short RNA-Seq reads by maximum likelihood is NP-hard

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q-bio.QM2013★ 2 cited

Isoform reconstruction using short RNA-Seq reads by maximum likelihood is NP-hard

Tianyang Li, Rui Jiang, Xuegong Zhang

Maximum likelihood is a popular technique for isoform reconstruction. Here, we show that isoform reconstruction using short RNA-Seq reads by maximum likelihood is NP-hard.