48 citations · 93 across the 3 of their papers we have counts for
7 papers
Two-Input Enzymatic Logic Gates Made Sigmoid by Modifications of the Biocatalytic Reaction Cascades
Oleksandr Zavalov, Vera Bocharova, Jan Halamek +6
Computing based on biochemical processes is a newest rapidly developing field of unconventional information and signal processing. In this paper we present results of our research…
A Biochemical Logic Approach to Biomarker-Activated Drug Release
V. Bocharova, O. Zavalov, K. MacVittie +7
The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---bi…
Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Enzyme Inhibition by a Substrate
Jan Halamek, Vera Bocharova, Mary A. Arugula +3
We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme (here horseradish peroxidase: HRP), the function of which can be inhibited by a substrate (hy…
Towards Biochemical Filter with Sigmoidal Response to pH Changes: Buffered Biocatalytic Signal Transduction
Marcos Pita, Vladimir Privman, Mary A. Arugula +3
We realize a biochemical filtering process by introducing a buffer in a biocatalytic signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl…
Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic
Vladimir Privman, Jan Halamek, Mary A. Arugula +3
The first realization of a designed, rather than natural, biochemical filter process is reported and analyzed as a promising network component for increasing the complexity of biom…
Optimization of Enzymatic Logic Gates and Networks for Noise Reduction and Stability
Mary A. Arugula, Jan Halamek, Evgeny Katz +4
Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemica…