2 papers
q-bio.GN2013
Genetic Complexity in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin
Soo-Young Park, Michael Z. Ludwig, Natalia A. Tamarina +11
Here we use Drosophila melanogaster to create a genetic model of human permanent neonatal diabetes mellitus and present experimental results describing dimensions of this complexit…
q-bio.PE2013
Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin
Bin Z. He, Michael Z. Ludwig, Desiree A. Dickerson +8
The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila…