2 papers
q-bio.GN2013
Causes and Consequences of genetic background effects illuminated by integrative genomic analysis
Christopher H. Chandler, Sudarshan Chari, David Tack +1
The phenotypic consequences of individual mutations are modulated by the wild type genetic background in which they occur.Although such background dependence is widely observed, we…
q-bio.GN2013
Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution
Chris H. Chandler, Sudarshan Chari, Ian Dworkin
The premise of genetic analysis is that a causal link exists between phenotypic and allelic variation. Yet it has long been documented that mutant phenotypes are not a simple resul…