2 citations · 2 across the 6 of their papers we have counts for
6 papers
Evolution at two levels of gene expression in yeast
Carlo G. Artieri, Hunter B. Fraser
Despite the greater functional importance of protein levels, our knowledge of gene expression evolution is based almost entirely on studies of mRNA levels. In contrast, our underst…
Cell-cycle regulated transcription associates with DNA replication timing in yeast and human
Hunter B. Fraser
Eukaryotic DNA replication follows a specific temporal program, with some genomic regions consistently replicating earlier than others, yet what determines this program is largely…
The molecular mechanism of a cis-regulatory adaptation in yeast
Jessica Chang, Yiqi Zhou, Xiaoli Hu +6
Despite recent advances in our ability to detect adaptive evolution involving the cis-regulation of gene expression, our knowledge of the molecular mechanisms underlying these adap…
A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers
Justin D. Smith, Kimberly F. McManus, Hunter B. Fraser
Measuring natural selection on genomic elements involved in the cis-regulation of gene expression -- such as transcriptional enhancers and promoters -- is critical for understandin…
Transcript length mediates developmental timing of gene expression across Drosophila
Carlo G. Artieri, Hunter B. Fraser
The time required to transcribe genes with long primary transcripts may limit their ability to be expressed in cells with short mitotic cycles, a phenomenon termed intron delay. As…
Synonymous codon usage and selection on proteins
Joshua B. Plotkin, Jonathan Dushoff, Michael M. Desai +1
Selection pressures on proteins are usually measured by comparing homologous nucleotide sequences (Zuckerkandl and Pauling 1965). Recently we introduced a novel method, termed `vol…