H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

Ji-Eun Lee, Chaochen Wang, Shiliyang Xu +7

Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases res…