3 papers
q-bio.PE2013
Error-prone polymerase activity causes multinucleotide mutations in humans
Kelley Harris, Rasmus Nielsen
About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single genera…
q-bio.PE2013
A model-based approach for identifying signatures of balancing selection in genetic data
Michael DeGiorgio, Kirk E. Lohmueller, Rasmus Nielsen
While much effort has focused on detecting positive and negative directional selection in the human genome, relatively little work has been devoted to balancing selection. This lac…
q-bio.PE2013
Natural selection reduced diversity on human Y chromosomes
Melissa A. Wilson Sayres, Kirk E. Lohmueller, Rasmus Nielsen
The human Y chromosome exhibits surprisingly low levels of genetic diversity. This could result from neutral processes if the effective population size of males is reduced relative…