2 papers
q-bio.PE2014
Reconstructing subclonal composition and evolution from whole genome sequencing of tumors
Amit G. Deshwar, Shankar Vembu, Christina K. Yung +3
Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, that can be applied to WGS data from one…
cs.LG2012
Inferring clonal evolution of tumors from single nucleotide somatic mutations
Wei Jiao, Shankar Vembu, Amit G. Deshwar +2
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases…