28 citations · 56 across the 3 of their papers we have counts for
5 papers
Negative Feedback and Physical Limits of Genes
Nicolae Radu Zabet
This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost…
Facilitated diffusion buffers noise in gene expression
Armin P. Schoech, Nicolae Radu Zabet
Transcription factors perform facilitated diffusion (3D diffusion in the cytosol and 1D diffusion on the DNA) when binding to their target sites to regulate gene expression. Here,…
Physical constraints determine the logic of bacterial promoter architectures
Daphne Ezer, Nicolae Radu Zabet, Boris Adryan
Site-specific transcription factors (TFs) bind to their target sites on the DNA, where they regulate the rate at which genes are transcribed. Bacterial TFs undergo facilitated diff…
The influence of transcription factor competition on the relationship between occupancy and affinity
Nicolae Radu Zabet, Robert Foy, Boris Adryan
Transcription factors (TFs) are proteins that bind to specific sites on the DNA and regulate gene activity. Identifying where TF molecules bind and how much time they spend on thei…
The effects of transcription factor competition on gene regulation
Nicolae Radu Zabet, Boris Adryan
Transcription factor (TF) molecules translocate by facilitated diffusion (a combination of 3D diffusion around and 1D random walk on the DNA). Despite the attention this mechanism…