3 papers
q-bio.PE2014
Comparing Nonparametric Bayesian Tree Priors for Clonal Reconstruction of Tumors
Amit G. Deshwar, Shankar Vembu, Quaid Morris
Statistical machine learning methods, especially nonparametric Bayesian methods, have become increasingly popular to infer clonal population structure of tumors. Here we describe t…
q-bio.PE2014
Reconstructing subclonal composition and evolution from whole genome sequencing of tumors
Amit G. Deshwar, Shankar Vembu, Christina K. Yung +3
Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, that can be applied to WGS data from one…
cs.LG2012
Inferring clonal evolution of tumors from single nucleotide somatic mutations
Wei Jiao, Shankar Vembu, Amit G. Deshwar +2
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases…