14.3k citations · 14.4k across the 3 of their papers we have counts for
3 papers
Second-generation PLINK: rising to the challenge of larger and richer datasets
Christopher C. Chang, Carson C. Chow, Laurent C. A. M. Tellier +3
PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imp…
Application of compressed sensing to genome wide association studies and genomic selection
Shashaank Vattikuti, James J. Lee, Christopher C. Chang +2
We show that the signal-processing paradigm known as compressed sensing (CS) is applicable to genome-wide association studies (GWAS) and genomic selection (GS). The aim of GWAS is…
The causal meaning of Fisher's average effect
James J. Lee, Carson C. Chow
In order to formulate the Fundamental Theorem of Natural Selection, Fisher defined the average excess and average effect of a gene substitution. Finding these notions to be somewha…