48 citations · 49 across the 4 of their papers we have counts for
4 papers
Detecting the Escherichia coli metabolic backbone
Oriol Güell, Francesc Sagués, M. Ángeles Serrano
The heterogeneity of reaction fluxes present in a metabolic network within a single flux state can be exploited to construct the so-called backbone as a reduced version of metaboli…
Mapping high-growth phenotypes in the flux space of microbial metabolism
Oriol Güell, Francesco Alessandro Massucci, Francesc Font-Clos +2
Experimental and empirical observations on cell metabolism cannot be understood as a whole without their integration into a consistent systematic framework. However, the characteri…
Essential plasticity and redundancy of metabolism unveiled by synthetic lethality analysis
Oriol Güell, Francesc Sagués, M. Ángeles Serrano
We unravel how functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks. We perform an exhaustive computational screeni…
Predicting effects of structural stress in a genome-reduced model bacterial metabolism
Oriol Güell, Francesc Sagués, M. Ángeles Serrano
We studied in silico effects of structural stress in Mycoplasma pneumoniae, a genome-reduced model bacterial organism, by tracking the damage propagating on its metabolic network a…