91 citations · 360 across the 7 of their papers we have counts for
8 papers
A multiscale mechanobiological model of bone remodelling predicts site-specific bone loss in the femur during osteoporosis and mechanical disuse
C. Lerebours, P. R. Buenzli, S. Scheiner +1
We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model inc…
Bone refilling in cortical bone multicellular units: Insights into tetracycline double labelling from a computational model
Pascal R. Buenzli, Peter Pivonka, David W. Smith
Bone remodelling is carried out by `bone multicellular units' (BMUs) in which active osteoclasts and active osteoblasts are spatially and temporally coupled. The refilling of new b…
Endocortical bone loss in osteoporosis: The role of bone surface availability
Pascal R. Buenzli, C. David L. Thomas, John G. Clement +1
Age-related bone loss and postmenopausal osteoporosis are disorders of bone remodelling, in which less bone is reformed than resorbed. Yet, this dysregulation of bone remodelling d…
The influence of bone surface availability in bone remodelling - A mathematical model including coupled geometrical and biomechanical regulations of bone cells
Peter Pivonka, Pascal R. Buenzli, Stefan Scheiner +2
Bone is a biomaterial undergoing continuous renewal. The renewal process is known as bone remodelling and is operated by bone-resorbing cells (osteoclasts) and bone-forming cells (…
Mechanobiological regulation of bone remodeling -- Theoretical development of a coupled systems biology-micromechanical approach
Stefan Scheiner, Peter Pivonka, Christian Hellmich +1
Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. I…
Modelling the anabolic response of bone using a cell population model
Pascal R. Buenzli, Peter Pivonka, Bruce S. Gardiner +1
To maintain bone mass during bone remodelling, coupling is required between bone resorption and bone formation. This coordination is achieved by a network of autocrine and paracrin…