Andrey V. Kuznetsov

collaborators

Showing q-bio.SCShow all

2 papers · 1 filter

q-bio.SC2026

Shorter but not more catalytic: an active-site-resolved model of how tau reshapes amyloid- $β$ secondary nucleation

Andrey V. Kuznetsov

Tau cross-seeding creates a mechanistic puzzle. Tau fibrils accelerate amyloid- $β$ 42 (A $β$ 42) nucleation and produce a larger population of shorter A $β$ fibrils, yet homotypic seco…

q-bio.SC2026

A kinetic model predicts that tau-catalyzed A $β$ nucleation can raise oligomer burden without increasing plaque volume

Andrey V. Kuznetsov

Tau and amyloid- $β$ (A $β$ ) deposits co-occur in Alzheimer's disease, and tau fibrils have recently been shown in vitro to catalyze A $β$ primary nucleation in a fold-specific manner…

Shorter but not more catalytic: an active-site-resolved model of how tau reshapes amyloid-β secondary nucleation

A kinetic model predicts that tau-catalyzed Aβ nucleation can raise oligomer burden without increasing plaque volume

Shorter but not more catalytic: an active-site-resolved model of how tau reshapes amyloid- $β$ secondary nucleation

A kinetic model predicts that tau-catalyzed A $β$ nucleation can raise oligomer burden without increasing plaque volume