2 papers
q-bio.BM2026
Expanding Protein Structure Prediction into Conformational State Space
Devlina Chakravarty, Justin J. Miller, Da Teng +9
Recent AI advances have enabled protein structure prediction at near-experimental accuracy, largely solving the problem of identifying a dominant conformation from sequence. Many p…
q-bio.BM2025
Fold-switching Proteins
Devlina Chakravarty, Lauren L. Porter
Globular proteins are expected to assume folds with fixed secondary structures, alpha-helices and beta-sheets. Fold-switching proteins challenge this expectation by remodeling thei…