Shear-induced unfolding and enzymatic cleavage of full-length VWF multimers

Svenja Lippok, Matthias Radtke, Tobias Obser +5

Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within t…