3 papers
q-bio.PE2026
Stochastic gradient descent on the epigenetic landscape: a unified framework for cellular plasticity, tumor heterogeneity, and the asymptotic irrelevance of fitness
Artur C. Fassoni
Phenotypic plasticity, the ability of cells to switch between states, is central to development, differentiation, and therapy resistance. Although it is modeled at several scales,…
math.AP2026
Fitness is asymptotically irrelevant under uniform competition in phenotype-structured populations
Artur César Fassoni
We prove that, in phenotype-structured populations under uniform competition, the long-term phenotypic distribution does not depend on the proliferation rates: it is the stationary…
q-bio.PE2016
An ecological resilience perspective on cancer: insights from a toy model
Artur C. Fassoni, Hyun M. Yang
In this paper we propose an ecological resilience point of view on cancer. This view is based on the analysis of a simple ODE model for the interactions between cancer and normal c…