6 papers
Applications of Large Language Models in Radiation Oncology: From Workflow Automation to Clinical Intelligence
Yuzhen Ding, Jason Holmes, Yuexing Hao +12
Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction.…
Causal machine learning reveals age-dependent radiation dose effects on mandibular osteoradionecrosis
Jingyuan Chen, Yunze Yang, Olivia M. Muller +8
Distinguishing causal relationships from statistical correlations remains a fundamental challenge in clinical research, limiting the translation of observational findings into inte…
Dose-LET Interactions Predict Capsular Contracture After Proton Postmastectomy Radiation Therapy
Jingyuan Chen, Zeliang Ma, Meiyun Cao +9
Pencil beam scanning (PBS) proton therapy provides highly conformal dose distributions that are increasingly leveraged for postmastectomy radiation therapy (PMRT) to reduce cardiop…
Causal Machine Learning Analysis of Empirical Relative Biological Effectiveness (RBE) for Mandible Osteoradionecrosis in Head and Neck Cancer Radiotherapy
Jingyuan Chen, Zhong Liu, Yunze Yang +8
Mandible Osteoradionecrosis (ORN) is one of the most severe adverse events (AEs) for head and neck (H&N) cancer radiotherapy. Previous retrospective investigations on real-world da…
Critical review of patient outcome study in head and neck cancer radiotherapy
Jingyuan Chen, Yunze Yang, Chenbin Liu +8
Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities cause…
Enabling Clinical Use of Linear Energy Transfer in Proton Therapy for Head and Neck Cancer -- A Review of Implications for Treatment Planning and Adverse Events Study
Jingyuan Chen, Yunze Yang, Hongying Feng +12
Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while spari…