417 citations · 432 across the 3 of their papers we have counts for
3 papers
q-bio.TO2016★ 15 cited
Optimized Treatment Schedules for Chronic Myeloid Leukemia
Qie He, Junfeng Zhu, David Dingli +2
Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to t…
q-bio.PE2013
A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues
B. Werner, D. Dingli, A. Traulsen
We model a general, hierarchically organized tissue by a multi compartment approach, allowing any number of mutations within a cell. We derive closed solutions for the deterministi…
q-bio.PE2007★ 417 cited
Genetic progression and the waiting time to cancer
Niko Beerenwinkel, Tibor Antal, David Dingli +5
Cancer results from genetic alterations that disturb the normal cooperative behavior of cells. Recent high-throughput genomic studies of cancer cells have shown that the mutational…