Showing stat.APShow all
2 papers · 1 filter
stat.AP2016
Adaptive seamless design for establishing pharmacokinetics and efficacy equivalence in developing biosimilars
Ryuji Uozumi, Chikuma Hamada
Recently, numerous pharmaceutical sponsors have expressed a great deal of interest in the development of biosimilars, which requires clinical trials to demonstrate the equivalence…
stat.AP2014
Interim decision-making strategies in adaptive designs for population selection considering post-progression survival magnitudes
Ryuji Uozumi, Chikuma Hamada
The development of targeted therapies, which benefit only a subgroup of patients treated for a given type of cancer, has been extremely attractive to many investigators. Adaptive s…