43 citations · 77 across the 3 of their papers we have counts for
4 papers
Ultraslow water-mediated transmembrane interactions regulate the activation of A adenosine receptor
Yoonji Lee, Songmi Kim, Sun Choi +1
Water molecules inside G-protein coupled receptor have recently been spotlighted in a series of crystal structures. To decipher the dynamics and functional roles of internal waters…
Communication over the network of binary switches regulates the activation of A adenosine receptor
Yoonji Lee, Sun Choi, Changbong Hyeon
Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the…
Mapping the intramolecular signal transduction of G-protein coupled receptors
Yoonji Lee, Sun Choi, Changbong Hyeon
G-protein coupled receptors (GPCRs), a major gatekeeper of extracellular signals on plasma membrane, are unarguably one of the most important therapeutic targets. Given the recent…
Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase
Yoonji Lee, Lak Shin Jeong, Sun Choi +1
S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important dru…