74 citations · 137 across the 2 of their papers we have counts for
2 papers
q-bio.CB2016★ 63 cited
A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns
William R. Holmes, JinSeok Park, Andre Levchenko +1
Cells crawling through tissues migrate inside a complex fibrous environment called the extracellular matrix (ECM), which provides signals regulating motility. Here we investigate o…
q-bio.MN2012★ 74 cited
Synthetic spatially graded Rac activation drives directed cell polarization and locomotion
Benjamin Lin, William R. Holmes, ChiaoChun Wang +5
Migrating cells possess intracellular gradients of Rho GTPases, but it is unknown whether these shallow gradients themselves can induce motility. Here we describe a new method to p…