Hydrolysis of Cephalexin and Meropenem by New Delhi Metallo $\beta$-Lactamase: Substrate Protonation Mechanism is Drug Dependent

Chandan Kumar Das, Nisanth N. Nair

Emergence of antibiotic resistance due to New Delhi Metallo $\beta$-lactamase (NDM-1) bacterial enzymes is of great concern due to their ability to hydrolyze wide range of antibiotics.…