419 citations · 843 across the 5 of their papers we have counts for
5 papers · 1 filter
A population genetic interpretation of GWAS findings for human quantitative traits
Yuval B. Simons, Kevin Bullaughey, Richard R. Hudson +1
GWAS in humans are revealing the genetic architecture of biomedical and anthropomorphic traits, i.e., the frequencies and effect sizes of variants that contribute to heritable vari…
Interpreting the dependence of mutation rates on age and time
Ziyue Gao, Minyoung J. Wyman, Guy Sella +1
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates th…
A genomic map of the effects of linked selection in Drosophila
Eyal Elyashiv, Shmuel Sattath, Tina T. Hu +5
Natural selection at one site shapes patterns of genetic variation at linked sites. Quantifying the effects of 'linked selection' on levels of genetic diversity is key to making re…
The deleterious mutation load is insensitive to recent population history
Yuval B. Simons, Michael C. Turchin, Jonathan K. Pritchard +1
Human populations have undergone dramatic changes in population size in the past 100,000 years, including a severe bottleneck of non-African populations and recent explosive popula…
Blood ties: ABO is a trans-species polymorphism in primates
Laure Ségurel, Emma E. Thompson, Timothée Flutre +9
The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polym…