3 papers
q-bio.CB2017
Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and small Rho-family GTPases
JinSeok Park, Deok-Ho Kim, Sagar R. Shah +7
Collective cell migration is a hallmark of developmental and patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epitheli…
q-bio.CB2016
A mechano-chemical feedback underlies co-existence of qualitatively distinct cell polarity patterns within diverse cell populations
JinSeok Park, William R. Holmes, Sung-Hoon Lee +7
Cell polarization and directional cell migration can display random, persistent and oscillatory dynamic patterns. However, it is not clear if these polarity patterns can be explain…
q-bio.CB2016
A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns
William R. Holmes, JinSeok Park, Andre Levchenko +1
Cells crawling through tissues migrate inside a complex fibrous environment called the extracellular matrix (ECM), which provides signals regulating motility. Here we investigate o…