906 citations · 928 across the 2 of their papers we have counts for
4 papers
Population-specific design of de-immunized protein biotherapeutics
Benjamin Schubert, Charlotta Schärfe, Pierre Dönnes +3
Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic…
Quantification of the effect of mutations using a global probability model of natural sequence variation
Thomas A. Hopf, John B. Ingraham, Frank J. Poelwijk +3
Modern biomedicine is challenged to predict the effects of genetic variation. Systematic functional assays of point mutants of proteins have provided valuable empirical information…
Sequence co-evolution gives 3D contacts and structures of protein complexes
Thomas A. Hopf, Charlotta P. I. Schärfe, João P. G. L. M. Rodrigues +4
Protein-protein interactions are fundamental to many biological processes. Experimental screens have identified tens of thousands of interactions and structural biology has provide…
3D Protein Structure Predicted from Sequence
Debora S. Marks, Lucy J. Colwell, Robert Sheridan +4
The evolutionary trajectory of a protein through sequence space is constrained by function and three-dimensional (3D) structure. Residues in spatial proximity tend to co-evolve, ye…