138 citations · 367 across the 5 of their papers we have counts for
5 papers
Reconstructing an epigenetic landscape using a genetic `pulling' approach
Michael Assaf, Shay Be'er, Elijah Roberts
Cells use genetic switches to shift between alternate stable gene expression states, e.g., to adapt to new environments or to follow a developmental pathway. Conceptually, these st…
The dynamics of simple gene-network motifs subject to extrinsic fluctuations
Elijah Roberts, Shay Be'er, Chris Bohrer +2
Cellular processes do not follow deterministic rules; even in identical environments genetically identical cells can make random choices leading to different phenotypes. This rando…
Cooperation dilemma in finite populations under fluctuating environments
Michael Assaf, Mauro Mobilia, Elijah Roberts
We present a novel approach allowing the study of rare events like fixation under fluctuating environments, modeled as extrinsic noise, in evolutionary processes characterized by t…
Extrinsic noise driven phenotype switching in a self-regulating gene
Michael Assaf, Elijah Roberts, Zaida Luthey-Schulten +1
Due to inherent noise in intracellular networks cellular decisions can be random, so genetically identical cells can display different phenotypic behavior even in identical environ…
Determining the stability of genetic switches: explicitly accounting for mRNA noise
Michael Assaf, Elijah Roberts, Zaida Luthey-Schulten
Cells use genetic switches to shift between alternate gene expression states, e.g., to adapt to new environments or to follow a developmental pathway. Here, we study the dynamics o…