The test-negative design with additional population controls: a practical approach to rapidly obtain information on the causes of the SARS-CoV-2 epidemic

Jan P Vandenbroucke, Elizabeth B Brickley, Christina M J E Vandenbroucke-Grauls +1

Testing of symptomatic persons for infection with SARS-CoV-2 is occurring worldwide. We propose two types of case-control studies that can be carried out jointly in test-settings f…