4 papers · 1 filter
Morphological instability of an invasive active-passive interface
Sumit Sinha, Haiqian Yang, L Mahadevan
Morphological instabilities of growing tissues that impinge on passive materials are typical of invasive cancers. To explain these instabilities in experiments on breast epithelial…
Controlling the morphologies and dynamics in three-dimensional tissues
Rajsekhar Das, Xin Li, Sumit Sinha +1
A number of factors, such as, cell-cell interactions and self-propulsion of cells driven by cytoskeletal forces determine tissue morphologies and dynamics. To explore the interplay…
Hamiltonian bridge: A physics-driven generative framework for targeted pattern control
Vishaal Krishnan, Sumit Sinha, L. Mahadevan
Patterns arise spontaneously in a range of systems spanning the sciences, and their study typically focuses on mechanisms to understand their evolution in space-time. Increasingly,…
Proliferation-driven mechanical feedback regulates cell dynamics in growing tissues
Sumit Sinha, Xin Li, Abdul N Malmi-Kakkada +1
Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn, cell growth and division induce active stresses in the tissue. As a consequence, t…