289 citations · 415 across the 5 of their papers we have counts for
5 papers
DCcov: Repositioning of Drugs and Drug Combinations for SARS-CoV-2 Infected Lung through Constraint-Based Modelling
Ali Kishk, Maria Pires Pacheco, Thomas Sauter
The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no effective antiviral drug except treatments for symptomatic therapy. Flux balance analysis is a…
Creation and analysis of biochemical constraint-based models: the COBRA Toolbox v3.0
Laurent Heirendt, Sylvain Arreckx, Thomas Pfau +52
COnstraint-Based Reconstruction and Analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental data and quantitative prediction of physico…
Fast reconstruction of compact context-specific metabolic networks via integration of microarray data
Maria Pires Pacheco, Thomas Sauter
Recently we proposed an algorithm for the fast reconstruction of compact context-specific metabolic networks (FASTCORE) that allowed dropping the reconstruction time to the time or…
Fast Reconstruction of Compact Context-Specific Metabolic Network Models
Nikos Vlassis, Maria Pires Pacheco, Thomas Sauter
Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of context-specific metabolic network models. The reconstruction of such a model from h…
A Study of the PDGF Signaling Pathway with PRISM
Qixia Yuan, Jun Pang, Sjouke Mauw +3
In this paper, we apply the probabilistic model checker PRISM to the analysis of a biological system -- the Platelet-Derived Growth Factor (PDGF) signaling pathway, demonstrating i…