3 papers
q-bio.QM2026
Quantifying the Spatiotemporal Dynamics of Engineered Cardiac Microbundles
Hiba Kobeissi, Samuel J. DePalma, Javiera Jilberto +3
Brightfield time-lapse imaging is widely used in cardiac tissue engineering, yet the absence of standardized, interpretable analytical frameworks limits reproducibility and cross-p…
q-bio.QM2025
SarcGraph for High-Throughput Regional Analysis of Sarcomere Organization and Contractile Function in 2D Cardiac Muscle Bundles
Saeed Mohammadzadeh, Yao-Chang Tsan, Aaron Renberg +3
Timelapse images of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide rich information on cell structure and contractile function. However, it is chall…
q-bio.QM2025
Quantifying HiPSC-CM Structural Organization at Scale with Deep Learning-Enhanced SarcGraph
Saeed Mohammadzadeh, Emma Lejeune
In cardiac cells, structural organization is an important indicator of cell maturity and healthy function. Healthy cardiomyocytes exhibit well-aligned morphology with densely packe…