116 citations · 149 across the 3 of their papers we have counts for
3 papers
The dissection of expression quantitative trait locus hotspots
Jianan Tian, Mark P. Keller, Aimee Teo Broman +4
Studies of the genetic loci that contribute to variation in gene expression frequently identify loci with broad effect on gene expression: expression quantitative trait locus (eQTL…
Identification and correction of sample mix-ups in expression genetic data: A case study
Karl W. Broman, Mark P. Keller, Aimee Teo Broman +4
In a mouse intercross with more than 500 animals and genome-wide gene expression data on six tissues, we identified a high proportion (18%) of sample mix-ups in the genotype data.…
Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes
Elias Chaibub Neto, Mark P. Keller, Alan D. Attie +1
Causal inference approaches in systems genetics exploit quantitative trait loci (QTL) genotypes to infer causal relationships among phenotypes. The genetic architecture of each phe…