5 papers
Platelet plug microstructure and flow modulate fibrin gelation dynamics: Insights from computational simulations
Janneke M. H. Cruts, Frank J. H. Gijsen, Aaron L. Fogelson +1
During the formation of a thrombus, the architecture of the growing platelet aggregate is heterogeneous, with areas of dense and loosely packed platelets. The surface of activated…
Mechanisms of thrombin inhibition by protein S and the TFPIα-fVshort-protein S complex
Alexander G. Ginsberg, Josefin Ahnström, James T. B. Crawley +5
Protein S (PS) is a notable anticoagulant implicated in both bleeding and thrombotic disorders, making it a promising drug target. Importantly, PS enhances the anticoagulant functi…
Adaptive Mesh Refinement for Two-Phase Viscoelastic Fluid Mixture Models
Bindi M. Nagda, Aaron Barrett, Boyce E. Griffith +2
Multiphase flows are an important class of fluid flow and their study facilitates the development of diverse applications in industrial, natural, and biomedical systems. We conside…
Modeling Platelet P2Y/ Pathway to Integrin Activation
Keshav B. Patel, Wolfgang Bergmeier, Aaron L. Fogelson
Through experimental studies, many details of the pathway of integrin activation by ADP during the platelet aggregation process have been mapped out. ADP binds t…
Flagellum Pumping Efficacy in Shear-Thinning Viscoelastic Fluids
Aaron Barrett, Aaron L. Fogelson, M. Gregory Forest +3
Microorganism motility often takes place within complex, viscoelastic fluid environments, e.g., sperm in cervicovaginal mucus and bacteria in biofilms. In such complex fluids, stra…