29 citations · 100 across the 5 of their papers we have counts for
5 papers
Genome-wide organization of eukaryotic pre-initiation complex is influenced by nonconsensus protein-DNA binding
Ariel Afek, David B. Lukatsky
Genome-wide binding preferences of the key components of eukaryotic pre-initiation complex (PIC) have been recently measured with high resolution in Saccharomyces cerevisiae by Rhe…
Nonspecific Protein-DNA Binding Is Widespread in the Yeast Genome
Ariel Afek, David B. Lukatsky
Recent genome-wide measurements of binding preferences of ~200 transcription regulators in the vicinity of transcription start sites in yeast, have provided a unique insight into t…
Nonspecific transcription factor-DNA binding influences nucleosome occupancy in yeast
Ariel Afek, Itamar Sela, Noa Musa-Lempel +1
Quantitative understanding of the principles regulating nucleosome occupancy on a genome-wide level is a central issue in eukaryotic genomics. Here, we address this question using…
Multi-scale sequence correlations increase proteome structural disorder and promiscuity
Ariel Afek, Eugene I. Shakhnovich, David B. Lukatsky
Numerous experiments demonstrate a high level of promiscuity and structural disorder in organismal proteomes. Here we ask the question what makes a protein promiscuous, i.e., prone…
Sequence correlations shape protein promiscuity
David B. Lukatsky, Ariel Afek, Eugene I. Shakhnovich
We predict analytically that diagonal correlations of amino acid positions within protein sequences statistically enhance protein propensity for nonspecific binding. We use the ter…